Liver Stem Cells: From
Preface to Advancements
Author(s):
Kanwal Rehman, Muhammad Javed Iqbal, Nureen
Zahra and Muhammad Sajid Hamid Akash Pages 10 - 21 ( 12 )
Abstract:
Liver is a major metabolic organ of the body
and is known to comprise of two epithelial cell lineages, namely, hepatocytes
and cholangiocytes which are known to originate from hepatoblasts during fetal
developing stages. Upon acute injury, the hepatocytes and cholangiocytes
undergo cellular division to compensate the loss, however, chronic damage may
suppress this proliferative ability and as a consequence hepatic and
extra-hepatic stem cells may contribute for liver regeneration. Facultative
liver stem cells (oval cells) may emerge, proliferate and contribute in
replacing damaged hepatic cells. Similarly, bone marrow and mesenchymal stem
cells are also known for contributing in liver regeneration having their
ability of self renewal and differentiation. However, a closer look is still
required to bridge the existing knowledge gaps between functionality and
limitations. Thereby, we have discussed the detailed mechanistic insights of
both hepatic and extra-hepatic stem cells including, stem/progenitor cells, adult/fetal
hepatocytes, oval cells, bone marrow and mesenchymal stem cells. We have also
focused on few in vitro and in vivo studies elucidating therapeutic
applications and challenges related to the liver stem cells. We believe that
such conversations may provide invaluable contribution for realistic
advancement in the state of therapeutic stem-cell transplantation.
Keywords:
Bioartificial liver, hepatocellular carcinoma,
hepatocytes, oval cells, stem/progenitor cells.
Affiliation:
Institute of Pharmacology, Toxicology and
Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
University Hangzhou, China and College of Pharmacy, Government College
University Faisalabad, Faisalabad, Pakistan.
For More Information Please Visit Our Website Current Stem Cell Research Therapy
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